肌肤初扪不觉很热,扪之稍久即感灼手,其临床意义是
患者,男,25岁。头晕1个月,高热,鼻衄1周来诊,心烦口渴,皮肤见瘀点及瘀斑,舌红绛苔黄燥,脉数。实验室检查:全血细胞减少,骨髓增生减低,无巨核细胞,治疗应首选的方剂是
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Lonely people, it seems, are at greater riskthan the gregarious of developing illnesses associated with chronicinflammation, such as heart disease and certain cancers. A paper published lastyear in the Public Library of Science, Medicine, shows the effect on mortalityof loneliness is comparable with thatof smoking and drinking after examining the results of 148 previous studies andcontrolled for factors such as age and pre-existing illness.
Steven Cole of the University ofCalifornia, Los Angeles, thinks he may know why this is so. He told theAmerican Association for the Advancement of Science meeting in Washington,D.C., about his work studying the expression of genes in lonely people. Dr.Cole harvested samples of white blood cells from both lonely and gregariouspeople. He then analysed the activity of their genes, as measured by theproduction of a substance called messenger RNA. This molecule carries instructions from the genes telling a cellwhich proteins to make. The level of messenger RNA from most genes was the samein both types of people. There were several dozen genes, however, that wereless active m the lonely, and several dozen others that were more active.Moreover, both the less active andthe more active gene types came from a small number of functional groups.
Broadly speaking, the genes less active in thelonely were those involved in staving off viral infections. Those that weremore active were involved in protecting against bacteria. Dr. Cole suspectsthis could help explain not only why the lonely are iller, but how, inevolutionary terms, this odd state of affairs has come about.
The crucial bit ofthe puzzle is that viruses have to be caught from another infected individual andthey are usually species-specific. Bacteria, in contrast, often just lurk inthe environment, and may thrive on manyhosts. The gregarious are therefore at greater risk than the lonely ofcatching viruses, and Dr. Cole thussuggests that past evolution has created a mechanism which causes white cellsto respond appropriately. Conversely, the lonely are better off ramping uptheir protection against bacterialinfection, which is a bigger relative risk to them.
What Dr. Cole seemsto have revealed, then, is a mechanism by which social environment reachesinside a person's body and tweaks its genome so that it responds appropriately.It is not that the lonely and the gregarious are genetically different fromeach other. Rather, their genes are regulated differently, according to howsociable an individual is. Dr. Cole thinks this regulation is part of a widermechanism that tunes individuals to the circumstances they find themselves in.
Broadly speaking, the genes more active in the lonely _______
《特种设备安全法》规定,特种设备的安装、改造、重大维修过程,必须经检验检测机构按照( )的要求进行监督检验,未经监督检验合格的不得出厂或者交付使用。