某新建项目建筑面积10000m2,按概算指标和地区材料预算单价等算出一般土建工程单价为1500元(人、料、机费用1200元,综合费率25%)。但新项目的设计资料与概算指标项目,其材料有部分变更:设计资料所用材料预算单价300元/T,而概算指标所用材料的预算单价220元/T,并且设计资料中每100m2建筑面积使用该材料6T,而概算指标中含4.5T。其余条件不考虑,则调整后的一般土建工程概算单价为( )元/m2。
以下属于光纤接入网缺点的是()。
甲到首饰店定制一对耳环,约定价格为2000元,6月6日甲到首饰店领取耳环。由于甲事务繁忙,甲在约定时间未到首饰店领取耳环。6月8日,首饰店旁边的商店起火,致使首饰店被烧毁大半,甲定制的耳环也被烧毁了。对此,下列选项中,正确的是( )。
6月6日为耳环的交付时间
耳环已经烧毁,甲不必向首饰店支付2000元
首饰店保管不善,甲可以要求首饰店赔偿损失
甲仍然需要向首饰店支付2000元
Passage1
Lonely people, it seems, are at greater riskthan the gregarious of developing illnesses associated with chronicinflammation, such as heart disease and certain cancers. A paper published lastyear in the Public Library of Science, Medicine, shows the effect on mortalityof loneliness is comparable with thatof smoking and drinking after examining the results of 148 previous studies andcontrolled for factors such as age and pre-existing illness.
Steven Cole of the University ofCalifornia, Los Angeles, thinks he may know why this is so. He told theAmerican Association for the Advancement of Science meeting in Washington,D.C., about his work studying the expression of genes in lonely people. Dr.Cole harvested samples of white blood cells from both lonely and gregariouspeople. He then analysed the activity of their genes, as measured by theproduction of a substance called messenger RNA. This molecule carries instructions from the genes telling a cellwhich proteins to make. The level of messenger RNA from most genes was the samein both types of people. There were several dozen genes, however, that wereless active m the lonely, and several dozen others that were more active.Moreover, both the less active andthe more active gene types came from a small number of functional groups.
Broadly speaking, the genes less active in thelonely were those involved in staving off viral infections. Those that weremore active were involved in protecting against bacteria. Dr. Cole suspectsthis could help explain not only why the lonely are iller, but how, inevolutionary terms, this odd state of affairs has come about.
The crucial bit ofthe puzzle is that viruses have to be caught from another infected individual andthey are usually species-specific. Bacteria, in contrast, often just lurk inthe environment, and may thrive on manyhosts. The gregarious are therefore at greater risk than the lonely ofcatching viruses, and Dr. Cole thussuggests that past evolution has created a mechanism which causes white cellsto respond appropriately. Conversely, the lonely are better off ramping uptheir protection against bacterialinfection, which is a bigger relative risk to them.
What Dr. Cole seemsto have revealed, then, is a mechanism by which social environment reachesinside a person's body and tweaks its genome so that it responds appropriately.It is not that the lonely and the gregarious are genetically different fromeach other. Rather, their genes are regulated differently, according to howsociable an individual is. Dr. Cole thinks this regulation is part of a widermechanism that tunes individuals to the circumstances they find themselves in.
Broadly speaking, the genes more active in the lonely _______